Download PDF Encephalitis lethargica

By Dr Ava Easton, Encephalitis Society

What is encephalitis lethargica?

Encephalitis lethargica (EL) is a serious and rare form of encephalitis. Since the late 16th century, epidemic outbreaks of disease that seems at least to have been similar to EL have been reported in various European countries. The name encephalitis lethargica itself was given by the neurologist Constantin Von Economo in 1916 at an early stage of the epidemic that happened during and after the First World War.

Difficulty of diagnosis and the lack of statistical records in many countries mean that estimates of the number of cases have varied greatly. Although reports vary, it seems that historically there was prevalence among males. Most cases are at the younger end of the age spectrum (up to 30/40 years old). There was little confirmed data around race and ethnicity although some reports suggested mortality was lower among black people.

For many years EL was regarded as a phenomenon of the past. In recent years there has been a recurrence of interest in the disease, concerning its cause and links with post-encephalitic Parkinsonism. The neurologist Oliver Sacks described the ‘awakenings’ of past cases, but recent papers have described contemporary cases and defined the disease in modern terms.

Modern reports suggest that perhaps half a million to a million or more people were affected, of whom about one-third died. Patients who survived EL often developed a form of Parkinsonism called post-encephalitic Parkinson's disease, which results in serious neurological disability. 

Causes

So far, the cause is unknown. Several opinions argued that it started from the 1919 influenza epidemic as either an acute viral, or a post viral syndrome. More recent work linking EL to a streptococcal infection may prove more compelling than the influenza theory. Although the last epidemic of EL occurred nearly a century ago, the cause was never scientifically established, and remains a matter of controversy today. This makes diagnosis difficult, and is one of the reasons why we do not know how many cases of EL there have been in recent times. We still see seeing sporadic cases of EL today. Some suspected EL may actually be NMDA-receptor encephalitis and therefore all suspected cases of EL should be tested for NMDA-receptor encephalitis.

Symptoms and diagnosis

The term ‘sleeping sickness’, where people seem to fall asleep or freeze whilst eating or working was first used to describe two cases in Vienna. However, the disease can present a wide and sometimes confusing range of symptoms, often with unusual and bizarre behaviour. There are indications that the majority of cases were referred to psychiatrists before being admitted to hospital if the symptoms progressed. It is often mistaken for epilepsy, hysteria, intoxication or a reaction to drugs.

Proposed diagnostic criteria for EL which has been widely accepted includes an acute or subacute encephalitic illness where all other known causes of encephalitis have been excluded. More recently it has been suggested that the diagnosis of LE may be considered if the patient’s condition cannot be attributed to any other known neurological condition and that they show the following signs: influenza-like signs; hypersomnolence (hypersomnia), wakeability, opthalmoplegia (paralysis of the muscles that control the movement of the eye), and psychiatric changes.

Treatment

There is no known cure and no clearly effective treatment. Historically, success has been claimed for steroids (anti-inflammatory drugs), anti-parkinson drugs and electroconvulsive therapy (ECT). During the initial stages of the illness, bodily functions need to be maintained, often involving intensive care therapy. As the condition settles it is a matter of maintaining and hopefully improving function by good physiotherapy, speech therapy and nutrition, as well as providing emotional support.

Outcome

Outcome is variable. Some people may make a full recovery, some patients die, and for others a Parkinsonian-type state may persist. Von Economo wrote "to look at these patients, one would suppose them to be in a state of profound secondary dementia. Emotions are scarcely noticeable in the face but they are mentally intact".

*Some information contained in this factsheet is courtesy of The Sophie Cameron Trust.


FS038V2 Encephalitis Lethargica

Date created: April 2014; Last updated: February 2017/ Review date: February 2020

Disclaimer: We try to ensure that the information is easy to understand, accurate and up-to-date as possible.

If you would like more information on the source material the author used to write this document please contact the Encephalitis Society. None of the authors of the above document has declared any conflict of interest which may arise from being named as an author of this document.