Pathogenesis of encephalitis

Characteristic Cytokine and Chemokine Profiles in Encephalitis of Infectious, Immune-Mediated, and Unknown Aetiology

Michael BD, Griffiths MJ, Granerod J, Brown D, Davies NWS, Borrow R, Solomon T

PLoS One. 2016;11(1):e0146288. doi: 10.1371/journal.pone.0146288

A complement-microglial axis drives synapse loss during virus-induced memory impairment

Michael J. Vasek, Charise Garber, Denise Dorsey, Douglas M. Durrant, Bryan Bollman, Allison Soung, Jinsheng Yu, Carlos Perez-Torres, Arnaud Frouin, Daniel K. Wilton, Kristen Funk, Bette K. DeMasters, Xiaoping Jiang, James R. Bowen, Steven Mennerick, John K. Robinson, Joel R. Garbow, Kenneth L. Tyler, Mehul S. Suthar,Robert E. Schmidt, Beth Stevens, Robyn S. Klein

Nature 534, 538-543 (23 June 2016) doi:10.1038/nature18283

Herpes simplex encephalitis is linked with selective mitochondrial damage; a post-mortem and in vitro study

Wnek, M., Ressel, L., Ricci, E. et al.

Acta Neuropathol (2016) 132: 433. doi:10.1007/s00401-016-1597-2

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NMDAR antibody encephalitis

NMDAR antibody encephalitis is an autoimmune disease that causes psychiatric features, confusion, memory loss and seizures followed by a movement disorder, loss of consciousness and changes in blood pressure, heart rate and temperature.
Herpes Simplex virus encephalitis

Herpes simplex encephalitis is a type of infectious encephalitis which happens when herpes simplex virus (HSV) enters the brain. Usually, it begins with ‘flu-like’ symptoms followed by neurological deterioration, which may include personality and behavioural changes, seizures, weakness and difficulties in communication.
What is encephalitis?

Encephalitis is an inflammation of the brain caused by an infection or through the immune system attacking the brain in error.
Guidelines for recovery

No two people with encephalitis have the same outcomes. People recover at different paces. Recovery can be helped by having lots of rest, good nutrition, helpful social network and support from professionals.
Limbic encephalitis

The term ‘limbic encephalitis’ (LE) describes the condition when limbic areas of the brain are inflamed (swollen) and consequently not functioning properly. Most forms of LE fall into two main categories: infectious encephalitis and autoimmune encephalitis.
Death from encephalitis

Encephalitis is a serious neurological condition and unfortunately, despite improvements in specific and more supportive treatments such as excellent intensive care management, encephalitis still has a high mortality (death) rate.
Encephalitis: after-effects, recovery and rehabilitation

This booklet provides key information about the type of issues that people may have after encephalitis, why rehabilitation/support from professionals and families are important and what options for self-help are available.
West Nile encephalitis

West Nile encephalitis is a type of infectious encephalitis caused by West Nile virus. People usually become infected after being bitten by a mosquito, which has fed on an infected bird.
Emotional and behavioural changes

Following encephalitis, some people may experience emotional and behavioural changes including low mood, increased anxiety, depression, mood swings, frustration, aggression, impulsivity, disinhibition, and/or poor emotional regulation.
Get support

Our Support Service is here to help you with any questions about encephalitis, recovery and rehabilitation or emotional support.